Lorenzo Pointer, 24, of Quitman, died in the one-vehicle accident at 7:30 p.m. Sunday on Interstate 59 north between the Enterprise exits.
Investigators say Pointer lost control of his vehicle and hit a concrete bridge pillar. They say he was not wearing a seat belt.
In all, eight people were killed in Mississippi and at least 11 in Alabama in roadway accidents over the holiday period.
In a crash Tuesday morning, Connie Shaffer, 47, of Philadelphia died in a two vehicle wreck on Highway 486 in Neshoba County.