The accident happened around 1 o'clock Saturday morning on Choctaw County Road 14 near Gilbertown.
Killed in the accident was 30-year-old Anetria Howard of Quitman.
One passenger, Jerry Frank of Stateline, Mississippi, was also injured. He was transported to Wayne General Hospital in Waynesboro, Mississippi for treatment.
Investigators say Howard lost control of the vehicle and left the roadway. They say she was not wearing a seat belt.