More than 300 Delta Airlines pilots marched near the company's headquarters Wednesday in Atlanta.
The pilots are in a dispute with management over the current contract.
Delta says it wants to reduce long-term pay and benefits up to $325 million. The pilots have authorized a strike, if that happens.
The Meridian, Miss., Regional Airport is served only by Delta partner, Atlantic Southeast Air Lines.
Airport Authority President Tom Williams said Wednesday it's unknown exactly what effect a strike by Delta pilots would have since it hasn't ever happened. But it is anticipated air travel from Meridian would be impacted because of connecting flights in Atlanta.
Delta is operating under bankruptcy protection and has said a pilot strike would put it out of business. Contract talks did continue Wednesday.