The Centers for Disease Control is making the grants available to help schools fight obesity.
Mississippi is among the worst in the nation in childhood obesity.
More than 25 percent of adults in Mississippi are obese and childhood obesity is rampant, according to the CDC.
Oxford Elementary School principal Larry Christman accepted his $40,000 grant from USDA Under Secretary Eric Bost Friday at the elementary school.
It's the first school to be selected as a grant winner out of 170 applicants.
The other 24 will be announced before the school year ends.