Patricia Ann Hannah was 16-years-old when she was murdered in April 1987, after she left a Greek show at Sumter County High School.
Her body was found a week later. Officials say an autopsy revealed she had been raped and suffocated.
Shelton Holloway, 20 at the time, was found guilty of the crime and sentenced to life in prison.
Both Holloway's and Hannah's families say, prior to being discovered, many of the girl's organs had been removed.
Because of this and Holloway's low IQ, they say they believe he is innocent and the case should be reopened.
"It's impossible for a person with an IQ of 30 to be able to pursue anything of this nature," said William Speight, a native of York and a filmmaker who took an interest in the case.
"I know my brother," said Theresa Jenkins. "He couldn't do nothing like this. Like I say, he's got like a child's mind."
Speight, who now lives in Atlanta, has produced a movie about this case, set for an April 2010 release.
Speight said he filed a petition two weeks ago with Alabama Attorney general Troy King requesting that he reopen the investigation.