The Mississippi Highway Patrol responded to a fatal wreck at 1:13 p.m. Monday on Interstate 59 in Clarke County.
Officials say the driver of a pickup truck traveling in the northbound lanes hit a bridge pillar in the median.
Thirty-two-year-old Raphael Roberts of Meridian died at the scene. His mother, Ola Roberts, 52, was transported to Anderson Hospital and later died.
A 14-year-old passenger is hospitalized in serious condition at Anderson's Hospital.