The one-vehicle accident happened around 4:00 p.m. Saturday on Buckatunna-Clara-Chicora Road.
Investigators say the truck left the road and flipped five times.
Emergency responders had to use the "jaws of life" to free someone on the passenger inside. The driver received minor injuries.
However, because of the severity of his injuries, the passenger had to have an arm amputated. Both vehicle occupants were from Texas.