Lauderdale County Coroner Clayton Cobler says one man and one woman were killed when their sedan collided with an 18-wheeler.
73-year-old Henry Lee Brown and his wife, Helen Brown, 69, died in the crash in Kewanee. It happened at the intersection of Kewanee Road and Highway 11/80.
The driver of the truck was transported to a local hospital.
The Mississippi Highway Patrol is investigating the cause.
The wreck was the second fatal accident reported in the county Tuesday.