Jackson, Miss. Both of Mississippi's U.S. senators voted Friday against legislation to fund the federal government through mid-November.
The measure did not include provisions that Republicans wanted, to block funding from the 2010 federal health overhaul law.
Mississippi Sens. Thad Cochran and Roger Wicker, both Republicans, issued statements Friday saying they want to repeal the health law that they consider expensive and intrusive.
The government funding measure passed the Democratic-controlled Senate. The 54-44 vote was split along party lines -- Democrats for, Republicans against.
But, the measure was expected to die in the Republican-controlled House, meaning a partial government shutdown is still possible.
Earlier Friday, Cochran and Wicker both voted for a procedural move to let the Senate consider a House measure that would've taken some money from the health law.