Burkhalter Rigging will begin moving two super loads toward the lignite coal plant in Kemper County Tuesday at 6 p.m.
The transport will move south from Brooksville to Shuqualak in the northbound lanes of Highway 45.
The Mississippi Department of Transportation, sheriffs departments and state troopers are acting as escorts throughout the night.
Officials say the southbound lanes will become a two-lane for traffic heading south and north.
Officials hope to get the load to Scooba by early Wednesday morning.