Chancery Judge J. Max Kilpatrick of Philadelphia will retire June 30.
Kilpatrick had announced in January that he would not seek re-election to the post he has held since July 1, 2005, after being appointed by Gov. Haley Barbour.
Philadelphia attorney D. Joseph Kilgore is the only candidate on the ballot for the November general election.
The Sixth Chancery Court District includes Attala, Carroll, Choctaw, Kemper, Neshoba and Winston counties.