Isaac caused serious damage in parts of Lauderdale County, as heavy rain and wind swept through east central Mississippi.
There were multiple reports of flooding in low lying areas and trees knocked down by wind or soaked earth.
William Lester, who lives on 52nd Avenue in Meridian, was awakened by the crashing of a tree through his roof.
"We heard a big bang about 7:30 and we didn't know what happened," said Lester. "I came out and looked and saw that tree on the roof, and that one piece setting there. I thought it was just a piece. I went back in the house and looked in the bathroom and it came slam through the roof."
Lauderdale Emergency Management Agency director David Sharp says Isaac made a thirty-mile jog to the east Wednesday night, putting Lauderdale County in its path.
"And we started having tornado warnings about 5 or 6 this morning," Sharp said. "Of course at that time we were not under a watch. We had not been notified of anything. And not even aware that thing had made that jog to the east."
Power companies were out Thursday restoring power and checking for the damage done by the storms.
Local police were also out to control the traffic where downed lines crossed the roads. Lester was among those who lost power.
"And then about an hour later the tile in the kitchen started falling," said Lester. "Then about twenty minutes after that, all the power went off."
The storms that came through Lauderdale County had EMEPA, Mississippi Power, and LEMA at full staff Thursday.