The marker will be placed Wednesday at the intersection of Mississippi Highway 3 and King Street in Vance, Miss.
Hooker, who was born in 1917, lived on farms in the Vance and Lambert areas as a child.
After stays in Memphis and Cincinnati, Hooker settled in Detroit in 1943, where he was based for many years.
He began recording in 1948 and had his first major hit in 1949 with "Boogie Chillen," which reached No. 1 on the R&B charts.
Hooker's distinctive "boogie" style harkened back to the earliest days of the blues with a mixture of down-home sounds.