Mississippi is poised to become only the second state in the nation to require a doctor's prescription for cold medicine containing pseudoephedrine, the main ingredient in the illicit drug methamphetamine.
The Senate Tuesday sent to the governor a bill that supporters say is designed to curtail the state's escalating meth activity. The House earlier passed the bill.
Gov. Haley Barbour has said he supports the legislation. Oregon passed a similar law in 2006.
Drug manufacturers had been pushing lawmakers to pass a real-time tracking system instead of the prescription bill.
Representatives of the industry have said the prescription bill will likely lead to meth addicts and cooks crossing state lines to get the drug.