Incumbent U.S. Rep. Gregg Harper defeated Hardy Caraway for the Republican nomination Tuesday in Mississippi's 3rd Congressional District.
The district crosses all or parts of 24 counties from Starkville southwest to Natchez.
Harper, 58, has promoted new treatments for developmental disorders, supported domestic energy production and pushed for more use of telemedicine.
Caraway, a 68-year-old Quitman resident, said he ran to promote industrial development and fight the power plant Mississippi Power Co. is building in Kemper County.
Harper raised $760,000 since his last election, spending $436,000. Caraway didn't file campaign finance reports.
Douglas MacArthur "Doug" Magee and Dennis Quinn were headed to a June 24 runoff for the Democratic nomination Tuesday in Mississippi's 3rd Congressional District.
Magee, a Mendenhall lawyer, campaigned against the impact of special interests in Congress.
Quinn, of Magnolia, ran in the 2011 Republican primary for a county supervisor seat in Pike County.
The two eliminated Jim Liljeberg, a teacher from Bay Springs.
Liljeberg and Quinn haven't filed campaign finance reports, while Magee reported raising no money.
The party nominees will face independent Roger Gerrard and Reform Party candidate Barbara Dale Washer in the general election Nov. 4.