Lowndes County Coroner Don Harris said 22-year-old Stephen Hunter Webb, of Clarksdale, died at the scene Saturday night from multiple injuries.
Harris said Webb was walking on Alternate U.S. 45 just south of the Clay County line when he was hit.
Mississippi Highway Patrol spokesman Steve Gladney said 20-year-old Andrea D. Smith, of West Point, was headed south when her car struck Webb.
Smith suffered moderate injuries and was taken to the Clay County Medical Center.
The accident is under investigation.
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