Casey Dick threw three touchdown passes and Felix Jones ran for two more as Arkansas beat Mississippi 44-8.
Jones rushed for 101 yards and Darren McFadden added 110 as Arkansas earned its first Southeastern Conference win of the season and the third victory in four games.
The loss leaves Ole Miss (2-6, 0-5 SEC) as the only SEC team without a conference victory this season.
It's the first time since 1984 that the Rebels started 0-5 in conference.
Jones put the Razorbacks (4-3, 1-3) up 14-0 in the first quarter with runs of 38 and 11 yards.
The two scoring runs were identical with Jones running off right tackle untouched to the end zone.
Ole Miss starter Seth Adams was pulled in the third quarter after throwing his fourth interception.
The senior was replaced by Brent Schaeffer, who threw both a late 37-yard touchdown pass and a 2-point conversion to Mike Wallace in the fourth quarter for Ole Miss' only points.
The scoring passes were the only positives in the passing game. The Rebels finished with 182 passing yards, the second lowest output of the season.
Adams threw 10 interceptions during the Rebels' 1-2 three-game homestand.