Drew Brees threw for 445 yards and three touchdowns, and Mike McKenzie returned an interception 75 yards for a score as the New Orleans Saints won their fourth straight by a 41-24 count over Jacksonville.
Brees completed 35 of 49 passes without an interception. Reggie Bush gained 115 total yards and scored touchdowns on a short run and a short reception.
Brees' other scoring passes went to Lance Moore and David Patten.
Maurice Jones-Drew returned a kickoff 100 years for the Jaguars. But Jacksonville's powerful running game was limited to 88 yards. Jacksonville also scored on an 80-yard touchdown pass from Quinn Gray to Reggie Williams.
The win puts the Saints -- who lost their first four games -- square into the NFC South race.