Chris Warren scored 20 points, Eniel Polynice added 18 and Mississippi's freshmen had one of their best games of the season in the 24th-ranked Rebels' 74-58 victory against No. 19 Vanderbilt Wednesday.
Led by Warren, freshmen scored 18 of Ole Miss' first 26 points in the pivotal opening minutes of the second half.
The Rebels (16-3, 3-3 Southeastern Conference) snapped a two-game losing streak and sent the Commodores (17-4, 2-4) to their fourth loss in five games.
The game was vital for two teams slumping after setting school records for consecutive wins to start the season.
The win snapped a six-game losing streak to Vanderbilt and helps the Rebels remain in the SEC West race behind one-loss Mississippi State after a brutal January run that included three ranked opponents.