Ron Polk, the Southeastern Conference's winningest coach, has resigned, Mississippi State officials said.
Athletic Director Larry Templeton said in a Thursday news release that Polk's resignation would take effect at the end of the season.
Polk is in his 29th season as head coach at Mississippi State and his 35th overall as a head coach.
He ranks among the nation's top 10 in career victories with 1,360 and has the fifth-most wins among active coaches.
Polk guided the Bulldogs to the College World Series last season and has taken 23 of 34 teams to NCAA regional play, including five straight.
He has clashed with the NCAA over recent rules changes and the school said Polk had told Templeton he would resign before the season began.