Keith Winstead raced home on a wild pitch from East Carolina pitcher Brett Butts in the 13th inning to give Southern Miss a 6-5 win in the first game of a doubleheader on Saturday.
Drew Carson went 3-of-7 with one RBI while James Ewing went 2-for-5 with 3 RBIs, including a solo home run.
J.R. Ballinger (2-0) got the victory for the Golden Eagles (20-9, 5-3 Conference USA).
Butts (1-1) took the loss for East Carolina (20-9, 4-4).
East Carolina shortstop Ryan Wood committed five errors in the game.
East Carolina won the nightcap 4-2, scoring three runs in the first inning off Southern Miss losing pitcher Barry Bowden.