Jeff Scott ran for two touchdowns and Mississippi piled up 304 yards rushing in a 39-0 victory over winless Tulane on Saturday.
The Ole Miss defense, seeking redemption after yielding 66 points in a loss to Texas a week earlier, limited Tulane to 159 yards of total offense.
The Rebels (3-1) constantly pressured Green Wave freshman quarterback Devin Powell. Making his first start, Powell was sacked three times and threw three interceptions. Tulane (0-3) also struggled to run, finishing with 14 net yards.
Playing for the first time since safety Devon Walker fractured his spine at Tulsa on Sept. 8, Tulane wore Walker's No. 18 on one side of its helmets. The similarly supportive Rebels had small "DW" stickers on their helmets.
Mississippi's Bo Wallace was 7 of 16 for 101 yards, including a 23-yard touchdown pass to Donte Moncrief. Randall Mackey and Ja-Mes Logan each added running touchdowns.