Senorise Perry rushed for 118 yards and two touchdowns, Jeremy Wright added 84 rushing yards and No. 19 Louisville rallied to beat Southern Miss 21-17 in a downpour on Saturday night.
Louisville (5-0) trailed 17-6 midway through the second quarter, but scored 15 unanswered points for the win, even though star quarterback Teddy Bridgewater was rendered nearly useless because of a driving storm that soaked the Roberts Stadium turf.
Perry scored both touchdowns during the rally. His 1-yard score pulled Louisville within 17-12 just before halftime and his 14-yard touchdown midway through the fourth quarter proved to be the game winner.
Louisville is off to its best start since 2006. Southern Miss (0-4) is in the midst of its worst start since 1976.
Southern Miss had a chance to win on the final drive, but a halfback pass by Desmond Johnson fell incomplete on fourth down.